ASYMMETRIC TRANSFER HYDROGENATION OF KETONES IN AQUEOUS SOLUTION CATALYZED BY RHODIUM (III) COMPLEXES WITH C2-SYMMETRIC FLUORENE-LIGANDS CONTAINING CHIRAL (1R, 2R)-CYCLOHEXANE-1, 2-DIAMINE

MONTALVO GONZALEZ, RUBEN; CHAVEZ, DANIEL; AGUIRRE, GERARDO; PARRA HAKE, MIGUEL; SOMANATHAN, RATNASAMY

dc.contributor.author	MONTALVO GONZALEZ, RUBEN
dc.contributor.author	CHAVEZ, DANIEL
dc.contributor.author	AGUIRRE, GERARDO
dc.contributor.author	PARRA HAKE, MIGUEL
dc.contributor.author	SOMANATHAN, RATNASAMY
dc.creator	123050	es_ES
dc.creator	0	es_ES
dc.creator	0	es_ES
dc.creator	0	es_ES
dc.creator	0	es_ES
dc.date.accessioned	2019-05-28T20:06:53Z
dc.date.available	2019-05-28T20:06:53Z
dc.date.issued	2010
dc.identifier	http://dx.doi.org/10.1590/S0103-50532010000300005	es_ES
dc.identifier.issn	0103-5053	es_ES
dc.identifier.uri	http://dspace.uan.mx:8080/jspui/handle/123456789/1970
dc.description	Two C2-symmetric bis(sulfonamide) ligands containing fluorene-chiral (1R,2R)-cyclohexane-1,2-diamine were complexed to RhIII(Cp*) and used as catalyst to reduce aromatic ketones. The corresponding chiral secondary alcohols were obtained in 87-100% ee and 85-99% yield, under asymmetric transfer hydrogenation (ATH) conditions using aqueous sodium formate as the hydride source. With acetophenone, 94% ee and 86-97% yield was achieved with substrate/catalyst (S/C) ratio of 10,000.	es_ES
dc.description.abstract	Dos ligandos de bis(sulfonamida) simétricos C2 que contienen flúor quiral (1R,2R)-ciclohexano-1,2-diamina fueron complejados a RhIII(Cp*) y usados como catalizador para reducir las cetonas aromáticas. Los correspondientes alcoholes secundarios quirales se obtuvieron en condiciones de hidrogenación por transferencia asimétrica (ATH) en un 87-100% de ee y 85-99% de rendimiento, utilizando como fuente de hidruros al formiato de sodio acuoso. Con acetofenona, el 94% de ee y el 86-97% de rendimiento se logró con una relación sustrato/catalizador (S/C) de 10,000.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Journal of the Brazilian Chemical Society	es_ES
dc.relation.uri	Público en general	es_ES
dc.rights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/cc-by-nc-sa	es_ES
dc.source	http://jbcs.sbq.org.br/imagebank/pdf/v21n3a05.pdf?agreq=Rub%C3%A9n%20Montalvo%20Gonz%C3%A1lez&agrep=jbcs,qn,qnesc,qnint,rvq	es_ES
dc.subject	ligandos de bis(sulfonamida)	es_ES
dc.subject	complejos RhIII(Cp*)	es_ES
dc.subject	hidrogenación por transferencia asimétrica	es_ES
dc.subject	bis(sulfonamide) ligands	es_ES
dc.subject	RhIII(Cp*) complexes	es_ES
dc.subject	asymmetric transfer hydrogenation	es_ES
dc.subject.classification	MEDICINA Y CIENCIAS DE LA SALUD [3]	es_ES
dc.title	ASYMMETRIC TRANSFER HYDROGENATION OF KETONES IN AQUEOUS SOLUTION CATALYZED BY RHODIUM (III) COMPLEXES WITH C2-SYMMETRIC FLUORENE-LIGANDS CONTAINING CHIRAL (1R, 2R)-CYCLOHEXANE-1, 2-DIAMINE	es_ES
dc.type	info:eu-repo/semantics/article	es_ES